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629 A randomized controlled trial in 60 individuals with pre-hypertension found supplementing with B vitamins (providing 10 mg B1, 10 mg B2, 100 mg B3, 50 mg B5, 3 mg B6, 1.5 mg B9, and 15 mcg B12) plus vitamin C (150 mg) daily for four months lowered levels of homocysteine and hs-CRP and reduced insulin resistance compared with placebo

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Their bioavailability is less affected by changes in liver function or blood flow but is more dependent on the extent of absorption from the gut The relationship F = 1 - E gives rise to an important, non-linear amplification effect that explains the dramatic nature of some drug-drug interactions for high-extraction drugs

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