Semaglutide weight loss data The STEP trial program, spanning multiple large-scale randomized controlled trials, established semaglutide as one of the most effective pharmacological weight loss interventions available
April 2026: As of April 1, there are now 73 pending cases in MDL 3163, which involves vision loss (non-arteritic anterior ischemic optic neuropathy) cases filed by people taking GLP-1 drugs, including Zepbound
10.1007/s12325-021-01789-5 [DOI] [PubMed] [Google Scholar] 76.Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL
Semaglutide is a GLP-1 receptor agonist (the same class as Wegovy and Ozempic) and tirzepatide is a dual GLP-1 and GIP receptor agonist (the class behind Mounjaro and Zepbound)
In one large study, people taking Semaglutide lost an average of 15-20% of their body weight over the course of a year