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doi: 10.1002/rcm.3583
In human islets, GLP-1 promotes increased connectivity between individual cells to improve calcium kinetics and insulin secretion throughout the islets, and promotes insulin secretion from islet cells when cells detect both elevated blood glucose levels and hormonal signals from the intestine
doi:10.1039/C8CC09185D 76
GHK-Cu operates through copper-mediated signaling without the retinoid irritation profile
This was evidenced by the downregulation of cytoplasmic mtDNA-related cGAS-STING and NLRP3 inflammasome signaling pathways, as well as reduced expression of proinflammatory factors IL6, IL1, and TNF- in Tibetan M9a+sh EPAS1 cells
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