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Inter-Laboratory Reproducibility and Interchangeability of 3R4F and 1R6F Reference Cigarettes in Mainstream Smoke Chemical Analysis and In Vitro Toxicity Assays Abstract A new reference cigarette, 1R6F, produced by the Kentucky Tobacco Research and Development Center, has been manufactured as a substitute for the 3R4F reference cigarette because of a depletion of 3R4F stock

"We compared all of our measurements against a standard reference cigarette

Our study also reveals non-significant CVD risk between modest-drinker and non-drinker (Table 2)

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