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As an add-on to background therapy, semaglutide demonstrated superiority to placebo in PIONEER 8 (semaglutide 3 mg, 7 mg, and 14 mg), PIONEER 4 (14 mg only), and in patients with renal impairment in PIONEER 5 (14 mg only)

Clinical trials show an average of 15% weight loss within 68 weeks, or about 15-16 months, with many participants showing up to 8% weight loss within 12 weeks

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Han D, Williams E, Cadenas E (2001) Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space