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Sakhaee K, Poindexter JR, Griffith CS, Pak CY

Carnitine has been trialed in cases of sepsis and found to retard protein loss without affecting protein metabolism in target tissues [94]

Clinical evidence for IGF-associated immunosuppression comes from reports of low tumor infiltrating lymphocytes (TILs) in high IGF-1R PCa bone metastases, and genomic aberrations in cancer patients with hyper-progressive disease post-ICB, including mutations in negative IGF regulator IGFBP2 and transcriptional upregulation of IGF-1, PI3K-AKT and ERK pathways 17,18

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