side effects of compounded tirzepatide Tirzepatide: Legal & Safe 2026 Has anyone had side effects

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Headline Numbers Intention-to-treat 3-point MACE: semaglutide associated with 29% lower risk versus tirzepatide (statistically significant) Intention-to-treat 5-point MACE: semaglutide associated with 22% lower risk (statistically significant) Per-protocol 3-point MACE: 57% lower risk for semaglutide Per-protocol 5-point MACE: 43% lower risk for semaglutide Absolute event rates: 0.1% (15 events) on semaglutide vs 0.4% (39 events) on tirzepatide The per-protocol numbers count only patients who actually stayed on their assigned drug

Individual factors such as age, existing gastrointestinal conditions, concurrent medications (particularly anticoagulants or corticosteroids), and duration of NSAID use all influence the safety profile

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