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Upon treating mucinous lung adenocarcinoma with the EGFR inhibitor gefitinib, the EGFR ligand amphiregulin promotes the binding of IGF-IR to importin-1 and triggers nuclear localization of IGF-IR, which in turn prevents the induction of apoptosis by gefitinib [117]

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The calculated clogP of 2.1 indicates a suitable lipophilicity

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Instead, we opted to produce meta-analysis estimates that are clinically relevant and meaningful by conducting separate analyses based on type of comparator (placebo, GLP-1 RAs and basal insulin) for each outcome