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Simultaneously, some cells undergo cell cycle arrest and become senescent owing to the inhibition of cyclin-dependent kinases mediated by p21 activation through the DDR pathway 11

Part of the problem is that without policies and procedures, the medical system doesnt have a way to code for it and quantify treatments.[ref] MCS is often initially caused by a sensitizing event , such as a strong exposure to a specific chemical

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Action: It reduces the acetylation of the NF-B p65 subunit, effectively silencing the transcription of pro-inflammatory cytokines

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