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GIP Agonism: Does It Help or Hurt

doi:10.1093/jn/132.4.636 Rosca MG, Lemieux H, Hoppel CL

It further emphasises potential complications, such as delayed gastric emptying, and calls for appropriate patient screening and further exploration of complication rates in this growing patient population [17]

The data on rhIGF-1 support the mechanistic rationale that an IGF-1 analog like LR3 (which has extended half-life and greater receptor availability in research settings) could enhance protein synthesis, stimulate cellular proliferation pathways and promote more efficient nutrient partitioning, though direct clinical trials of IGF-1 LR3 itself in humans are lacking

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