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As a result of such negative effects on total body neuroendocrine homeostasis, it is advisable to select an intervention that is sufficiently high on the feedback loop to avoid negatively impacting as much of it as possible
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in the ninth trial, the dose was 15 mg/kg/day for 182 days
This is mostly because the majority of the systematic reviews and randomised clinical trials measure changes in body fat percentage or body composition, rather than more specific, regional fat loss
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