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The FDA reviewed similar reports in January 2024 and did not find a causal link, but the symptoms remain in the review record

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These organelles vary in size and shape depending on the source and metabolic status, but are often ellipsoids of about 5 microns in diameter and 1 micron long

Clubbing of digits may be seen in untreated TOF with prolonged cyanosis

Furthermore, the impairment of mitophagy following HIF-1 knockdown faithfully modeled the inhibitor treatment phenotype, an effect that was partially attenuated upon NIX overexpression (Supplementary Fig