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These pathways are both serotonergic (eg, rostral ventral medulla) and noradrenergic (eg, dorsolateral pontine tegmentum), converging into the dorsal lateral funiculus, which synapse in rexeds laminae I, II and V in the spinal cord dorsal horn
The recommendation to cycle off is based on caution, not hard evidence
Thymosin alpha-1 appears to promote a more tolerogenic dendritic cell phenotype, meaning these cells are more likely to induce tolerance rather than activation when they encounter self-antigens