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Liu J, Liu M, Ye X, Liu K, Huang J, Wang L, et al

Not chasing trends blindly, but choosing treatments that are medically guided, personalised, and realistic

This is relevant, as thiazides in general have been proposed to promote metabolic dysregulation by inhibiting insulin secretory responses to nutrients through their hypokalemic effects (Zillich et al., 2006), and perhaps by direct effects on renal gluconeogenesis (Fulgraff et al., 1972)

For deeper or stubborn dark spots, additional targeted treatments may be needed

Because neuropathy is becoming more common, costs are rising, and medicines dont fully solve the problem, both patients and doctors are turning to these safer, evidence-based approaches