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Toxicol Lett 161(2):159166

doi: 10.1038/oby.2006.118 13 HolsenLMSavageCRMartinLEBruceASLeppingRJKoEet al

These early insights from the COURAGE trial are consistent with recently published pre-clinical data in rodents and non-human primates, and clearly establish the principle that blocking GDF8 with or without activin A can preserve muscle and further increase fat loss in patients being treated with GLP-1 therapy, thereby improving the quality of weight loss