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Contraindicated in Wilson's disease and active liver disease

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"Centenarians display plasma MOTS-c concentrations significantly higher than age-matched peers, a pattern that closely resembles levels found in individuals decades younger suggesting preserved mitochondrial signaling as a hallmark of exceptional longevity." The connection to cellular senescence deserves further attention here

A week-long gap during weeks 1 through 4 of loading could delay the tissue saturation that makes maintenance effective