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Interestingly, chronic oral administration of rotenone to rodents in vivo induces many key features of PD, including selectively and progressive nigrostriatal DA neurodegeneration, abnormal behaviours (not seen in the MPTP mouse model) and formation of Lewy bodies (not seen in either the MPTP or 6-OHDA mouse model) 30

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Data Availability Statement Data availability statement: This population-based study obtained data from the TrinetX platform (accessible at for which third-party restrictions apply to the availability of this data

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3234 In addition, a study reported GLP-1R expression on pericytes, which are multi-functional mural cells located at the center of the neurovascular unit (NVU)