In a double-blind placebo-controlled trial by El-Salhy et al., 164 IBS patients were treated with 30g or 60g of donor stool or their own stool (as a placebo) via endoscopic injection into the upper gastrointestinal tract (156)
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108, 109 Thereby, insulin levels are only slightly decreased, but drop significantly together with blood glucose levels and body weight once calorie intake is also restricted
The long-term follow-up of the UKPDS study showed a significant 24% reduction in microvascular disease and a 15% reduction in macrovascular complications, such as myocardial infarction, along with a 13% reduction in all-cause mortality [6]
Standard of Care (EXAMINE) study, 5,280 patients with type 2 diabetes and either an acute myocardial infarction or unstable angina requiring hospitalization within the previous 1590 days were randomized to alogliptin or placebo in addition to existing glucose-lowering and cardiovascular drug therapy for a median follow-up of 1.5 years
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