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Additionally, the number of adults over 80 years old will triple and reach 426 million ( Therefore, it seems to be of utmost importance to develop strategies and interventions that interfere with the aging process, prevent or at least mitigate age-associated diseases, and support healthy aging patterns, not only to elongate the lifespan but also to increase the healthspan - the phase of life spent in health, active, and in absent of chronic diseases ( 2 Telomere biology: the basics and beyond A comprehensive understanding of the underlying mechanisms of aging and their impact on long-term health provides valuable insights into resilience mechanisms, their influence on stress responses, and the ensuing effects on health ( 2.1 Telomere shortening: at the nexus of cellular aging In 2013, telomere attrition was described as a primary hallmark of aging (Wang et al., 2018

Free Radic Biol Med 33:8393 Khanna S, Roy S, Packer L, Sen CK (1999) Cytokine-induced glucose uptake in skeletal muscle: redox regulation and the role of alpha-lipoic acid

In T 1 DM, an autoimmune mechanism impairs -cells, leading to insulin deficiency, whereas T 2 DM is characterized by insulin resistance and impaired glucose regulation, where the peripheral action of insulin is compromised (3)

Related: GLP-1 users to drive 35% of food, drink sales by 2030 Looking for a reprint of this article