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The study revealed that despite elevated PD-L1 expression, the effectiveness of immunotherapy was suboptimal, as indicated by brief remission periods and reduced PFS compared to MET-focused treatment [123]

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Moreover, the JAK2 inhibitor AG490 diminished SINs inhibitory effect on TNF-, indicating that SIN exerts anti-inflammatory actions by activating the 7nAChR/JAK2/STAT3 pathway

This varies significantly among individuals based on metabolism, lifestyle factors, and treatment response