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Within the mitochondria itaconate inhibits the succinate dehydrogenase (SDH) complex which results in reduced flow of carbons through the TCA cycle as well as inhibition of oxidative phosphorylation since TCA cycle SDH is also complex II of the electron transport chain

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Most osteoarthritis treatmentssuch as NSAIDs, steroid injections or physical therapyfocus on symptom control rather than underlying mechanical drivers, says Dr

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