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For example, the SELECT trial clearly demonstrated that semaglutide significantly reduces the risk of major adverse cardiovascular events (MACE), leading to FDA approval for lowering the risk of cardiovascular death, myocardial infarction, or stroke in overweight or obese adults with established cardiovascular disease (Marso et al., 2016a)

Pioneer 1: Randomized clinical trial of the efficacy and safety of oral semaglutide monotherapy in comparison with placebo in patients with type 2 diabetes

In people who lose weight rapidly, theres an increased risk of gallstones, as there would be with any kind of rapid weight loss

Insulin therapy, including Toujeo, typically causes weight gain