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Samples were collected from the reactors into sterilised 100 mL Duran bottles with bromobutyl rubber stoppers, pre-flushed with sterilised N 2 gas for 5 min

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Heise T, Mari A, DeVries JH et al (2022) Effects of subcutaneous tirzepatide versus placebo or semaglutide on pancreatic islet function and insulin sensitivity in adults with type 2 diabetes: a multicentre, randomised, double-blind, parallel-arm, phase 1 clinical trial

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Growth hormone pathways interact with insulin sensitivity and glucose metabolism areas that retatrutide also directly modulates creating a theoretical risk of unpredictable glycaemic effects, including both hypoglycaemia and hyperglycaemia