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Pain 32 , 10051010 (2016)

NRF 2 interacts with kelch-like ECH-associated protein-1 (KEAP1) and targets KEAP1-Cullin3-mediated polyubiquitination and proteasomal degradation under non-stress settings ( Normally, ATF4 and NRF2 work together to control gene expression

32 In people who are deficient or have mutations in the enzymes that catalyze the production of glutathione from homocysteine, the methylation cycle will be under pressure to remove excess homocysteine