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For those concerned about side effects Tirzepatide has the best overall tolerability profile in clinical trials, with the lowest discontinuation rates

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According to NICE Clinical Knowledge Summaries, the choice of laxative should be based on stool consistency, with macrogol commonly used and particularly effective for faecal loading

Federally-regulated outsourcing facilities may sell tirzepatide until March 19, 2025, and semaglutide until May 22, 2025

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