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28,29 Koike et al reported that treatment with vitamin C prevented cigarette smoke-induced emphysema and restored lung tissue damage in protein-30 knockout (SMP30-KO) mice characterized by accelerated aging

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In case of autoimmune components, auto-antibodies directed at fetal brain proteins might cause BBB damage (Zimmerman et al., 2007)

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Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism