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In 2023, the FDA approved tirzepatide for obesity, which, according to Gratzl and colleagues, contributed to an increase in prescribing trends of GLP-1 medications

Combining CagriSema (which contains semaglutide) with tirzepatide (which activates GLP-1 receptors) would result in excessive GLP-1 pathway stimulation, likely producing severe gastrointestinal side effects

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The study reviewed 79 websites offering compounded GLP-1 receptor agonists like semaglutide and tirzepatide and found notable transparency issues: Compounded drugs are often produced during shortages of brand-name medications but lack FDA oversight for safety and efficacy

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