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Hence, there is evidence for the hypothesis that pathophysiological mechanisms underlying olfactory dysfunction are directly caused by a lack of orexin-A [126]
In the sections below, we review mechanisms, evidence, safety considerations and practical options for researchers and clinicians
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Circulation 107:13591365 Yasumura EG, Stilhano RS, Samoto VY, Matsumoto PK, de Carvalho LP, Valero Lapchik VB, Han SW (2012) Treatment of mouse limb ischemia with an integrative hypoxia-responsive vector expressing the vascular endothelial growth factor gene
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