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Toxicol Pathol 31:471479 Gupta S, Natarajan R, Payne SG, Studer EJ, Spiegel S, Dent P, Hylemon PB (2004) Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes

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Several researchers have proposed intranasal delivery to reduce first-pass degradation and allow direct olfactory-pathway CNS access