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BAT regulates energy expenditure through a process known as adaptive thermogenesis, in which uncoupling protein-1 (UCP1, a BAT marker) uncouples mitochondria respiration to generate heat instead of adenosine triphosphate [7]

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The regression-like pattern is seldom documented with dermoscopic monitoring, but is peculiar enough to allow a clinicopathological differential diagnosis between melanoma with regression and its main benign simulator, the so-called sclerosing nevus with pseudomelanomatous features or compound nevus with regression-like fibrosis (58, 59)