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DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45

In column chromatography methods, protein lysates are eluted through columns that are packed with polymer particles

Even with advanced matching, this is observational data

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It is also indirectly responsible for cystine uptake via the cystine/glutamate antiporter system that reduces to cysteine, another rate-limiting precursor in glutathione synthesis [12]