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These findings illustrate the potential of TCMs and natural products to beneficially modulate the gut-kidney axis, thereby alleviating AKI and potentially preventing its progression to CKD ( Figure 5 )

In healthy subjects, subcutaneous injections of GLP-2 elicit a dose-related decrease in CTX-1 (a bone resorption marker), which has sparked suggestions for the use of GLP-2 as a potential osteoporosis treatment [68]

Silibinin alleviates ferroptosis of rat islet cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy

The EHBD injury was visible at 2 weeks of age and progressed over time, quantified by duct score as described in the Methods section

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