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Sean Wharton was not surprised to learn about a surge in shady websites selling what are alleged to be counterfeit versions of popular weight-loss and diabetes drugs like Ozempic

However, in this trial, weight loss response to semaglutide 2.4 mg at 68 weeks was not related to meal-stimulated endogenous GLP-1 response at baseline, suggesting that the supraphysiological effect of semaglutide probably overrides the biological mechanisms linked to a suboptimal clinical response

Its something scientists could explore in future studies along with how apitegromab and related drugs work in older, frailer people

However, evidence supporting its efficacy is limited, and it may lead to an undesirable increase in blood pressure

Risks of Individual Cancers in the Pooled Tirzepatide versus Control (Pooled and Individual) Groups RR, risk ratio