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In this context, our data with nifedipine can be understood

In a PWS mouse model, a progressive central leptin insensitivity has been observed and it predicted the reduction in the anorexic leptin-mediated effect and the energy expenditure, likely through the impairment of the activation of leptin-responsive pro-opiomelanocortin neurons and the release of the melanocortin receptor agonist -melanocyte-stimulating hormone [12]

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It changes the hormonal signal your brain receives so hunger stops running the show