Kong X, Feng D, Mathews S, Gao B
Systemic effect across multiple sites
A vicious cycle is formed, in which primary bone marrow dysfunction causes iron overload, which in turn amplifies bone marrow dysfunction
Under the stimulation of high mechanical stress, activation of the PIEZO1 protein leads to a decrease in the intracellular GSH level of chondrocytes, a reduction in the function and expression of GPX4, and a significant increase in the intracellular calcium ion concentration, ultimately inducing ferroptosis of chondrocytes
Plusieurs tudes indpendantes ont reproduit les rsultats initiaux de l'quipe de Sikiric concernant la gurison des ulcres gastriques et des lsions tendineuses, renforant la crdibilit de ces observations