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In particular, further research is needed to assess the response in specific subgroups, such as patients with higher BMI, and to compare clinical features between patients with and without muscle cramps to validate these findings

Comparative safety profile and discontinuation rates of incretin-based therapies in MASLD/MASH clinical trials In certain regions, nearly one-third of patients discontinue GLP-1 RA therapy within the first year of initiation [72]

These figures are promising but require confirmation in the ongoing phase 3 TRIUMPH programme before any conclusions about superiority over approved agents can be drawn

Unfortunately, due to rapid industrialization, emissions of metals to the environment have increased and now exceed those from natural sources

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