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And semaglutide specifically has been shown to reduce neuropathic pain in diabetic rats by inhibiting spinal neuroinflammation [8], and a 2025 review in the Korean Journal of Pain concluded that GLP-1 receptor agonists have real potential in neuropathic pain management [20]

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Thyroid Medication and GLP-1 Therapy If youre on thyroid medications such as levothyroxine, liothyronine, or desiccated thyroid extract, weight loss from GLP-1 therapy could increase your risk of hyperthyroidism

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