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The mechanism may involve improved endothelial function and reduced oxidative stresspotentially relevant even in early or subclinical cases

While it is generally well tolerated, some users report difficulty falling asleep or staying asleep, particularly early in treatment or after dose increases

September 2023: Nearly six years after launch, the company adds ileus and bowel obstruction warnings after patients suffered excruciating intestinal blockages requiring emergency surgery

However, some patients may experience changes in urination patterns indirectly related to semaglutide