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The active compound in milk thistle, silymarin, works by increasing the production of glutathione in the liver

Redox Biology, 2017

However, for optimal results, these medications should be used in conjunction with a healthy, balanced diet for overall metabolic health

And the cherry on top

The women drawn to this approach tend to fall into three overlapping groups: those who've finished a weight-loss phase and would like to keep the result without staying on a full dose forever, those whose bodies respond so strongly that the standard schedule always felt like driving with the pedal floored, and those who never wanted dramatic weight loss in the first place, just relief from the food noise and appetite chaos that showed up somewhere in perimenopause and refused to leave