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In agreement with the decrease in TEER and increase in BBB paracellular permeability, tight junction proteins and adherens junction protein, -catenin, expression and localization are also altered with LPS treatment [71]

[DOI] [PubMed] [Google Scholar] [169].Rao RK, Samak G

Researchers also identified a new class of compounds, "PIPI drugs" (Psychedelic drug Informed but Psychedelic experience Inactive), that retain therapeutic benefits without evoking psychedelic experiences, opening entirely new frontiers for the treatment of mental health and inflammatory disease

While the goal is to restore normal regulation, there is a theoretical risk of pushing the immune system in an unintended direction

10.3390/polym14183791 12 AloneziS.TusiimireJ.WallaceJ.DuftonM