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Here, we use a large mammalian animal model with cardiac electrophysiological properties close to that of humans 45 to test the hypothesis that (i) the chronotropic effect of GLP-1 is independent of the autonomic nervous system, (ii) the chronotropic effect of GLP-1 is a direct effect on the heart through the GLP-1 receptor, (iii) GLP-1 affects electrophysiological properties of the sinus node, (iv) the chronotropic effect is mediated by changes of the phosphorylation state of key proteins that control Ca 2+ homeostasis in myocytes, and (v) the signalling effect is elicited in pacemaker myocytes in the sinus node

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Obesity, like high blood pressure or diabetes, is a chronic condition that often requires long-term management rather than a short-term fix

GLP-1 diabetes drugs could stop anxiety and depression worsening, study finds

Temperature is one of the most critical factors