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Description

Together these modifications dramatically reduce binding to IGF-binding proteins (IGFBPs), extending the free fraction half-life from approximately 10-15 minutes for native IGF-1 to roughly 20-30 hours for IGF-1 LR3

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Studies showed influences on growth hormone secretion, prolactin levels, cortisol/corticosterone rhythms, luteinizing hormone, and possibly other pituitary and peripheral hormones

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This process includes upregulated scavenger receptor A expression, activation of FASN, and increased LDL uptake, ultimately impairing DC function

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