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Some of the so far reported short-term effects are accumulation of toxins on the skin, irritation, (micro) inflammation, oxygen deficiency, clogging of pores, impairment of skin barrier, dryness / lack of moisture, excessive desquamation, pigment spots, altered metabolism as well as protein, lipid, and DNA oxidation

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Food and Drug Administration, (2022), "FDA approves treatment for weight management in patients with Bardet-Biedl Syndrome aged 6 or older"

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Additionally, the included studies did not report the probable side effects of supplements