The most plausible hypothesis isnt drug toxicity
Single and dual agonists The fundamental difference between these two molecules is that semaglutide is a GLP-1 agonist, i.e., it has a strong structural similarity (95%) with this hormone and specifically activates its receptor, while tirzepatide is a dual agonist, i.e., it has a hybrid structure that allows it to activate both GLP-1 and GIP receptors (Figure 2)
This work suggests that HGF-MET may also protect from parthanatos, a form of caspase-independent regulated cell death occurring especially in neurons and driven by PARP1 hyperactivation ( Oxidative DNA stress occurring after cerebral ischemia is associated with a decrease in apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) expression (Niimura et al., 2006c)
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