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GLP-1 receptor agonists have shown good effects in normalizing insulin desensitization
That is, EGT could couple GSH to reduce ferryl myoglobin, chelate transition metal iron to scavenge ROS/RNS and free radicals generated during IR, regulate proinflammatory cytokines like interleukin-1 (IL-1) and tumor necrosis factor- (TNF-), and ultimately prevent myocardial injury (Servillo et al., 2017a)
Future success will likely hinge on multi-target strategies that simultaneously inhibit -syn toxicity, rectify iron dyshomeostasis, and harness the supportive functions of gliaall tailored to disease stage and individual patient profiles
After excluding one withdrawn study, 27 Phase II and III trials conducted by pharmaceutical companies that assessed cognition in schizophrenia were analyzed
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