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By stabilizing cardiolipin, SS-31 prevents electron leakage at its source, improving ATP generation while reducing oxidative stress

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10.1007/s12035-020-02277-7 167 ZhangH.GuoJ.ChuJ.YuH.ZhangJ.MaS.et al (2025)

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The neuroprotective effects provided by the three supplemented diets following MPTP-neurotoxicity were not due to impairment of the metabolism of MPTP, since the striatal tissue levels of its metabolite MPP + (1-methyl-4-phenyl-pyridinium ion) showed no differences between the control diet (11.6 0.79 ng/mg protein, n = 12) and the combination diet treated mice (10.9 0.70 ng/mg protein, n = 12), when measured after 28 days of chronic treatment with MPTP (40 mg/kg/day for 28 days)