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This single amino acid swap makes semaglutide nearly resistant to DPP-4 degradation, the enzyme that destroys natural GLP-1 within minutes

Nausea was reported in 42.4% of patients on the 12 mg dose, with diarrhoea and constipation affecting 32% and 26.1% respectively

Dinner: salmon with broccoli and sweet potato

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It slows gastric emptying meaning food leaves the stomach more slowly which extends post-meal fullness