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Native GLP-1 remains in the bloodstream for only a few minutes, so alterations to the molecule (amino acid changes or side chain additions) are required to make it resistant to the effect of dipeptidyl peptidase-4 (1,2)

One study found a type of weight loss surgery known as sleeve gastrectomy was associated with a decrease in shoe size a year later.

Keep detailed notes on appetite changes, any side effects, and weight trends during the first month on the new peptide

While some individuals may lose a small amount of weight in the first week due to reduced calorie intake, substantial weight loss usually takes longer

Mayo Clinic Prescription weight-loss drugs Plain-language clinician-reviewed background on GLP-1 medications, common side effects, and when to seek care