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When blood glucose levels are 5 mmol/L or less, GLP-1 has no effect, and may even increase glucagon secretion

Glucose-dependent insulinotropic polypeptide (GIP) receptor agonists In addition to being a GLP-1 RA, tirzepatide is also an agonist of GIP, a gut hormone that impacts glucose and fat metabolism.13 Its similar to GLP-1 in that it stimulates insulin secretion from the pancreas, and research shows that the two hormones work synergistically to increase weight loss

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Action of tyrosinase on alpha and beta-arbutin: A kinetic study