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However, those with a BMI of 27 or higher may also be eligible if they have related medical conditions like type 2 diabetes, hypertension, high cholesterol, or obstructive sleep apnea

Diabetes also is associated with an elevated risk of macrovascular complications including myocardial ischemia and strokes

Furthermore, all discussed reports evaluate only acute effects of the treatment, and evaluation of long-term effects of the GLP-1R stimulation on the alcohol intake has not yet been reported

Further trials are required in order to establish whether these dual GLP-1/glucagon agonists are superior to GLP-1 analogues, and whether the glucagon activity might reverse some of the improvements in glycaemia seen with GLP-1 analogues alone